Catechol-O-Methyl Transferase (COMT) inhibitors
- COMT inhibitors block the action of Catechol -O- Methyl Transferase which is the enzyme involved in break down of levodopa.
- Examples of COMT inhibitors are Entacapone and Tolcapone.(5)
- COMT inhibitors must be used in combination with levodopa.
- Dry mouth.
- Loss of appetite.
- Since COMT inhibitors are used with levodopa, side effects related to levodopa may been seen, for example dyskinesia.(16)