- Antimuscarinic drugs block the action of acetylcholine which is a neurotransmitter that helps transmit messages between nerve cells and muscles.
- Antimuscarinics are used in drug induced parkinsonism.
- These include procyclidine and trihexyphenidyl hydrochloride.(6)
- Tardive dyskinesia cannot be improved with the use of these drugs.(18)
Antimuscarinic side effects
- Dry mouth.
- Blurred vision.
- Urination problems.(18)
- Domperidone is the most popular choice to relieve symptoms of nausea and vomiting in Parkinson’s.(7)
- The risk of extrapyramidal side effects is minimal however there is an increased risk of cardiac events which should be considered before use.