Monoamine oxidase B inhibitors
- MAO–B inhibitors can help improve the use of dopamine by nerve cells by blocking an enzyme called monoamine oxidase type B which breaks down dopamine.
- Blocking this enzyme = increase in dopamine = fewer Parkinson’s symptoms.
- MAO-B inhibitors include rasagiline and selegiline.(12, 13)
- Selegiline is metabolised into amphetamine, patients should be aware of drug driving laws.(14)
- Unlike other antiparkinsons drugs the dose does not need to be increased gradually.
- Aching joints.
- Flu-like symptoms.
- Avoid consumption of tryamine rich food such as salami with selegiline because it can lead to a dangerous spike in blood pressure.(15)